Researchers have not pinpointed an exact cause of Alzheimer’s. However, like other complex neurological diseases, such as multiple sclerosis and schizophrenia, they do know that multiple factors contribute to the development of Alzheimer’s. These factors indicate the possibility of a person who is at-risk to develop the disease.
Although not all the risk factors are known, there are several that have been consistently proven to be part of the underlying cause:
- 65 years old and older. The risk doubles for every five years over the age of 65.
- Family history. The combination of genetics and environment may contribute to the cause.
- Genetics. The APOE-e4 mutation is the first gene to be found and has the greatest impact.
Research continues to investigate the other possible contributing factors, to isolate and treat the disease.
Symptoms and Effects
There are two known effects that Alzheimer’s has on the brain. The first is the formation of a beta-amyloid plaque. This protein forms clusters in specific areas of the brain that disrupt the exchange of neurotransmitters at the synapses, preventing the neurons from working properly. The loss of cellular function causes inflammation, which leads to the immune system to attack the injured cells. The plaque also prevents absorption of nutrients, essentially starving the cells.
The second effect is the formation of tangles inside the neuron. These tangles make twisted protein fibers called tau that prevent the transport of nutrients inside the neuron, leading to cellular starvation.
Symptoms from the development of Alzheimer’s varies from individual-to-individual. According to the Alzheimer’s Association, there are 10 common warning signs and symptoms:
- Challenges in problem solving and planning.
- Confusion with time and place.
- Memory loss.
- Difficulty completing familiar tasks.
- Problems with speaking or writing.
- Withdrawal from work and social functions.
- Changes in personality.
- Poor judgement.
- Misplaced items.
- Trouble with visual or spatial images.
With early detection, people can begin treatment which may provide some https://www.acheterviagrafr24.com/viagra-pharmacie/ relief, help with both cognitive and behavioral symptoms, and improve their quality of life.
Current Treatment for Alzheimer’s Disease
There are several FDA approved medications for people with Alzheimer’s Disease: Aricept, Exelon, Namenda, Namzaric, and Razadyne. These are cholinesterase inhibitors, used to prevent the breakdown of acetylcholine—an important neurotransmitter for memory and learning.
“Unfortunately, medications like Aricept cause more systemic side effects when taken at higher doses, because the medication spreads throughout the body,” explained Kelli K. Maw, MD, MPH, Meridien’s Principal Investigator at their Brooksville clinic. “Currently, there are medications being tested that enhance the effects of these cholinesterase inhibitors. These newer drugs could potentially minimize the side effects and allow for higher doses of medication to target the brain.”
More research is needed to understand the effects of these medications. The only way to better treatment, prevention and a cure for Alzheimer’s Disease is through the support and participation in clinical research trials. To learn more about Meridien Research’s Alzheimer’s Disease clinical research trials, call 888-777-8839 or submit a confidential inquiry to: email@example.com.